convulsil 2.0mg 🇹🇭

Mechanism of Action

Clonazepam enhances the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. This action produces anxiolytic, anticonvulsant, sedative, and muscle relaxant effects.

Therapeutic Indications

**Treatment of various seizure disorders, including absence seizures, myoclonic seizures, and Lennox-Gastaut syndrome.

**Management of panic disorders.

**Adjunctive therapy for certain movement disorders.

Precautions and Side Effects

Common Side Effects:

**Drowsiness

**Dizziness

**Fatigue

**Impaired coordination

Serious Side Effects:

**Respiratory depression

**Dependence and withdrawal symptoms

**Cognitive impairment

Precautions:

**Use with caution in patients with respiratory disorders, hepatic or renal impairment.

**Avoid abrupt discontinuation to prevent withdrawal symptoms.

**Not recommended during pregnancy and lactation unless clearly necessary.

Historical Background

Clonazepam was first synthesized in 1960 and introduced into clinical practice in 1975. It has since been widely used for its efficacy in treating seizure disorders and panic attacks.

Misuse and Abuse Potential

As a benzodiazepine, clonazepam has the potential for misuse and dependence. It is classified as a Schedule IV controlled substance in many countries.

Additional Information

**Pregnancy: Clonazepam crosses the placenta and may cause fetal harm. Use only if the potential benefit justifies the potential risk.

**Lactation: Excreted in breast milk; caution is advised.

**Pediatric Use: Safety and efficacy in children have been established for certain indications.